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Free Pick Breakdown, Odds & Prediction: 49ers vs. Cardinals (11/21/2022)

By Wendi Oliveros
November 21, 2022
Photo by: Rob Schumacher - The Republic

San Francisco 49ers vs. Arizona Cardinals (11/21 @ 8:15 PM EST.)

Spread: San Francisco (-7.5)
Total: Over 43.5

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Overview and Betting Info

It has taken until Week 11 for the San Francisco 49ers and Arizona Cardinals to meet for the first time this season. This Monday night game will be played in Mexico City; the Cardinals are considered the home team in this international contest. These two NFC West rivals have their second meeting in Week 18 in San Francisco.

The NFC West is a competitive division led by the surprising Seattle Seahawks at 6-4. The 49ers, on a two-game winning streak, are one game back at 5-4. On the 49ers heels, are the Cardinals at 4-6 fresh off a Week 10 win over the Super Bowl Champion Los Angeles Rams who sit in last place in the division at 3-6.

San Francisco 49ers

The 49ers are ranked 10th in the Pro Football Talk’s Week 11 rankings. At 5-4, they are picking up wins, maybe not in a dominating or a pretty way, but they are getting the job done with Jimmy Garoppolo at quarterback and with the addition of Christian McCaffrey. McCaffrey was not as dominant in the Week 10 win over the Chargers; he had only 38 yards rushing. However, the Cardinals need to account for him since he has four touchdowns, two rushing, one receiving, and one passing, in three games as a 49er.

The 49ers are also relatively healthy at this crucial point of the season with defensive tackle Arik Armstead the only player ruled out for the game.

Arizona Cardinals

Quarterback Kyler Murray’s hamstring injury sidelined him for the Los Angeles Rams game. The Cardinals have a very capable backup in veteran Colt McCoy though he was banged up in the Rams game and started the week limited in practice with a knee injury.

Murray’s availability is shaping up to be a game time decision though he has been progressing well. His mobility is a concern given that the injury is a hamstring one. McCoy is well enough to go in his place if necessary.

Wide receiver DeAndre Hopkins is also dealing with a hamstring injury that makes him questionable for the game. The Cardinals enter the game ranked 20th in Pro Football Talk’s Week 11 ratings. That is up three spots from Week 10. Are the Cardinals are healthy enough to build on the momentum and confidence gained from the Week 10 win over the Rams?

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